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SR ONE CAPITAL MANAGEMENT, LP 13F portfolio summary

SR ONE CAPITAL MANAGEMENT, LP of SR ONE CAPITAL MANAGEMENT, LP has 15 current stock holdings with a reported portfolio value of $1.04B. The portfolio 1 year return is +97.68%. Top holdings include MANE (28.42%), ZBIO (12.31%), CRSP (10.70%), AVLN (10.48%), DSGN (9.09%).

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SR ONE CAPITAL MANAGEMENT, LP

SR ONE CAPITAL MANAGEMENT, LP
Latest filing: 2026-06-30

SR ONE CAPITAL MANAGEMENT, LP runs SR ONE CAPITAL MANAGEMENT, LP and currently holds 15 stock positions, which is fewer than the average of 230 among the investors we track. The portfolio is valued at approximately $1.04B. Their top holdings are MANE, ZBIO, CRSP, AVLN, DSGN. The top five represent 71.0% of reported portfolio weight. SR ONE CAPITAL MANAGEMENT, LP ranks #172 out of 1000 investors tracked by Alpha Score. In the most recent quarter, SR ONE CAPITAL MANAGEMENT, LP initiated 1 new position. They added to 1 existing position. Their current best-performing preview position is MANE with returns of +94.68%.

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Top 5 Holdings
MANE28.4%
ZBIO12.3%
CRSP10.7%
AVLN10.5%
DSGN9.1%
Top 5: 71.0%
Portfolio Returns
1 Year
+97.68%
#62/1000
3 Year
+156.20%
#109/1000
5 Year
+72.16%
#521/1000

Portfolio Value

$1.04B

Alpha Score

97.5

#172 of 1000

Holdings

15

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15 stock holdings

HoldingWeightAvg BuyCurrentReturnQuarter Change
MANE
Veradermics, Inc.
28.42%$63.15$102.97+63.05%
Held
ZBIO
Zenas BioPharma, Inc
12.31%$17.41$32.29+85.47%
Held
CRSP
CRISPR Therapeutics AG
10.70%$66.54$59.50-10.58%
Held
AV
AVLN
Avalyn Pharma, Inc
10.48%$32.92$38.37+16.56%
New Buy
DSGN
Design Therapeutics, Inc.
9.09%$19.87$14.99-24.56%
Held
ALMS
Alumis Inc.
5.31%$12.54$24.17+92.74%
Held
ORIC
ORIC Pharmaceuticals, Inc.
4.81%$10.16$14.20+39.76%
Added
+2.23%
MLYS
Mineralys Therapeutics Inc.
4.06%$15.55$25.65+64.95%
Held
SPRY
ARS Pharmaceuticals, Inc.
3.09%$8.02$5.51-31.36%
Held
RARE
Ultragenyx Pharmaceutical Inc.
0.44%$23.00$25.83+12.30%
Held

Showing 1-10 of 15